In healthy subjects, prasugrel increased bupropion cmax and auc values by 14 and 18 , respectively, and decreased cmax and auc values of hydroxybupropion, an active metabolite of bupropion, by 32 and 24 , respectively.
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the effect of hepatic impairment on the pharmacokinetics of bupropion was characterized in 2 single-dose trials, one in subjects with alcoholic liver disease and one in subjects with mild-to-severe cirrhosis.
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