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Posted on 13. Mai 2018 · Posted in Allgemein

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methotrexate in high doses followed by leucovorin rescue in combination with other chemotherapeutic agents is effective in prolonging relapse-free survival in patients with non-metastatic osteosarcoma who have undergone surgical resection or amputation for the primary tumor.

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during the period following l-asparaginase protein inhibition, there is a period of increased dna synthesis that leads to increased sensitivity to methotrexate.

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in animals and in humans, probenecid has been reported to increase plasma concentrations of methotrexate see warnings .

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